ALS Information for Patients and Caregivers

What are Rilutek tablets?

Rilutek is the first effective treatment for people with ALS. Laboratory studies suggest that Rilutek is “neuroprotective,” which means it protects nerve cells from damage. Many researchers believe that Rilutek protects the nerve cells by what they describe as “glutamate (pronounced glue-tah-mate) inhibition.” Researchers also believe that this activity could explain the effect Rilutek has on the survival of people with ALS.

The human body naturally produces glutamate, which carries signals to the motor neurons. This is one link in the chain of how the brain tells the muscles what to do. One of several theories researchers have is that in people with ALS, parts of the nervous system are overexposed to glutamate. A buildup of glutamate has been seen early in the progression of this disease. Too much glutamate “burns out” the motor neurons so that they can’t carry the brain’s messages to the muscles to tell them what to do.

The active ingredient in Rilutek is riluzole (pronounced rill-you-zole). Sanofi-aventis is the company that distributes Rilutek.

Important Safety Information

You should not take Rilutek if you are allergic to any of its ingredients.
Call your doctor if you have a fever while taking Rilutek.
Rilutek may cause you to feel dizzy, light-headed, or sleepy. If you experience any of these, you should NOT drive a vehicle or use machinery.
If you miss or skip a dose of Rilutek, do not take any extra tablets to make up for those you missed, but take your prescribed dose at the next regularly scheduled time.
When taking Rilutek, avoid drinking excessive amounts of alcohol; alcohol may contribute to compromising liver function and may be associated with an increased risk of liver problems.
The most common side effects of Rilutek are weakness, nausea, lung function decrease*, a mild liver disorder that is typically temporary, runny nose and headache. If any side effects become troublesome, contact your doctor.
Be sure to tell your doctor and pharmacist about all other medicines you are taking, including nonprescription products and vitamins. If you have questions, please talk to your doctor.